PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation
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چکیده
PGC-1α was initially identified as a PPARγ-interacting protein from the brown adipose tissue and was subsequently found to associate with many nuclear receptors and transcription factors. Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fasting in the liver, and exercise in the skeletal muscle. In this short review, we describe the molecular features and skeletal muscle metabolism function of PGC-1α.
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تاریخ انتشار 2016